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Polymorphisms in cytochrome P450 are associated with extensive efavirenz pharmacokinetics and CNS toxicities in an HIV cohort in Botswana.
Vujkovic, Marijana; Bellamy, Scarlett L; Zuppa, Athena F; Gastonguay, Marc R; Moorthy, Ganesh S; Ratshaa, Bakgaki; Han, Xiaoyan; Steenhoff, Andrew P; Mosepele, Mosepele; Strom, Brian L; Bisson, Gregory P; Aplenc, Richard; Gross, Robert.
Afiliação
  • Vujkovic M; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Bellamy SL; Department of Epidemiology and Biostatistics, Dornsife School of Public Health, Drexel University, Philadelphia, PA, USA.
  • Zuppa AF; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Gastonguay MR; Metrum Research Group, Tariffville, CT, USA.
  • Moorthy GS; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Ratshaa B; Botswana UPenn Partnership, Gaborone, Botswana.
  • Han X; Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Steenhoff AP; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Mosepele M; Department of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Strom BL; Faculty of Medicine, University of Botswana, Gaborone, Botswana.
  • Bisson GP; Rutgers Biomedical and Health Sciences, Newark, NJ, USA.
  • Aplenc R; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Gross R; Department of Medicine (Infectious Diseases), University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Pharmacogenomics J ; 18(5): 678-688, 2018 09.
Article em En | MEDLINE | ID: mdl-29855606

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Sistema Nervoso Central / Polimorfismo de Nucleotídeo Único / Sistema Enzimático do Citocromo P-450 / Benzoxazinas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: Pharmacogenomics J Assunto da revista: BIOLOGIA MOLECULAR / FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Sistema Nervoso Central / Polimorfismo de Nucleotídeo Único / Sistema Enzimático do Citocromo P-450 / Benzoxazinas Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Africa Idioma: En Revista: Pharmacogenomics J Assunto da revista: BIOLOGIA MOLECULAR / FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos