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Safety, tolerability and pharmacokinetics/pharmacodynamics of the adrenomedullin antibody adrecizumab in a first-in-human study and during experimental human endotoxaemia in healthy subjects.
Geven, Christopher; van Lier, Dirk; Blet, Alice; Peelen, Roel; Ten Elzen, Bas; Mebazaa, Alexandre; Kox, Matthijs; Pickkers, Peter.
Afiliação
  • Geven C; Department of Intensive Care Medicine, Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, HP: 710, PO Box 9101, 6500, HB, Nijmegen, The Netherlands.
  • van Lier D; Department of Intensive Care Medicine, Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, HP: 710, PO Box 9101, 6500, HB, Nijmegen, The Netherlands.
  • Blet A; Department of Anesthesia, Burn and Critical Care, University Hospitals Saint-Louis - Lariboisière, AP-HP, Paris, France.
  • Peelen R; UMR-S 942, Inserm, Paris, France.
  • Ten Elzen B; Sorbonne Paris Cité, Paris Diderot University, Paris, France.
  • Mebazaa A; Department of Intensive Care Medicine, Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, HP: 710, PO Box 9101, 6500, HB, Nijmegen, The Netherlands.
  • Kox M; Department of Intensive Care Medicine, Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, HP: 710, PO Box 9101, 6500, HB, Nijmegen, The Netherlands.
  • Pickkers P; Department of Anesthesia, Burn and Critical Care, University Hospitals Saint-Louis - Lariboisière, AP-HP, Paris, France.
Br J Clin Pharmacol ; 84(9): 2129-2141, 2018 09.
Article em En | MEDLINE | ID: mdl-29856470
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endotoxemia / Adrenomedulina / Anticorpos Monoclonais Humanizados Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endotoxemia / Adrenomedulina / Anticorpos Monoclonais Humanizados Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda País de publicação: Reino Unido