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Alterations in the Gut ( Gallus gallus) Microbiota Following the Consumption of Zinc Biofortified Wheat ( Triticum aestivum)-Based Diet.
Reed, Spenser; Knez, Marija; Uzan, Atara; Stangoulis, James C R; Glahn, Raymond P; Koren, Omry; Tako, Elad.
Afiliação
  • Reed S; College of Medicine , University of Arizona , Tucson , Arizona 85724 , United States.
  • Knez M; USDA/ARS, Robert W. Holley Center for Agriculture and Health , Cornell University , Ithaca , New York 14853 , United States.
  • Uzan A; College of Science and Engineering , Flinders University , Adelaide South Australia 5001 , Australia.
  • Stangoulis JCR; Azrieli Faculty of Medicine , Bar-Ilan University , Safed 1311502 , Israel.
  • Glahn RP; College of Science and Engineering , Flinders University , Adelaide South Australia 5001 , Australia.
  • Koren O; USDA/ARS, Robert W. Holley Center for Agriculture and Health , Cornell University , Ithaca , New York 14853 , United States.
  • Tako E; Azrieli Faculty of Medicine , Bar-Ilan University , Safed 1311502 , Israel.
J Agric Food Chem ; 66(25): 6291-6299, 2018 Jun 27.
Article em En | MEDLINE | ID: mdl-29871482
The structure and function of cecal microbiota following the consumption of a zinc (Zn) biofortified wheat diet was evaluated in a well-studied animal model of human nutrition ( Gallus gallus) during a six-week efficacy trial. Using 16S rRNA gene sequencing, a significant increase in ß- but not α-microbial diversity was observed in the animals receiving the Zn biofortified wheat diet, relative to the control. No significant taxonomic differences were found between the two groups. Linear discriminant analysis revealed a group of metagenomic biomarkers that delineated the Zn replete versus Zn deficient phenotypes, such that enrichment of lactic acid bacteria and concomitant increases in Zn-dependent bacterial metabolic pathways were observed in the Zn biofortified group, and expansion of mucin-degraders and specific bacterial groups able to participate in maintaining host Zn homeostasis were observed in the control group. Additionally, the Ruminococcus genus appeared to be a key player in delineating the Zn replete microbiota from the control group, as it strongly predicts host Zn adequacy. Our data demonstrate that the gut microbiome associated with Zn biofortified wheat ingestion is unique and may influence host Zn status. Microbiota analysis in biofortification trials represents a crucial area for study as Zn biofortified diets are increasingly delivered on a population-wide scale.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triticum / Zinco / Alimentos Fortificados / Galinhas / Microbioma Gastrointestinal / Ração Animal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Agric Food Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triticum / Zinco / Alimentos Fortificados / Galinhas / Microbioma Gastrointestinal / Ração Animal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Agric Food Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos