Purinergic receptors and neglected tropical diseases: why ignore purinergic signaling in the search for new molecular targets?
J Bioenerg Biomembr
; 50(4): 307-313, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-29882206
ABSTRACT
Purinergic receptors are widespread in the human organism and are involved in several physiological functions like neurotransmission, nociception, platelet aggregation, etc. In the immune system, they may regulate the expression and release of pro-inflammatory factors as well as the activation and death of several cell types. It is already described the participation of some purinergic receptors in the inflammation and pathological processes, such as a few neglected tropical diseases (NTDs) which affect more than 1 billion people in the world. Although the high social influence those diseases represent endemic countries, most of them do not have an efficient, safe or affordable drug treatment. In that way, this review aims to discuss the current literature involving purinergic receptor and immune response to NTDs pathogens, which may contribute in the search for new therapeutic possibilities.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medicina Tropical
/
Receptores Purinérgicos
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Doenças Negligenciadas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Bioenerg Biomembr
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Brasil