Direct synthesis of N-terminal thiazolidine-containing peptide thioesters from peptide hydrazides.
Chem Commun (Camb)
; 54(66): 9127-9130, 2018 Aug 14.
Article
em En
| MEDLINE
| ID: mdl-29882948
ABSTRACT
We report a simple and promising synthetic method to oxidize peptide hydrazides containing N-terminal thiazolidine as a protected cysteine. This yields the corresponding thioester via a peptide azide without decomposition of the thiazolidine ring. The newly developed protocol was validated by the synthesis of the bioactive peptide LacZα.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Ésteres
/
Tiazolidinas
/
Hidrazinas
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Japão