Marijuana use differentially affects cannabinoid receptor expression in early gestational human endometrium and placenta.
Placenta
; 66: 36-39, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-29884300
ABSTRACT
Marijuana is one of the most abused drugs among pregnant women leading to maternal and fetal abnormalities. Cannabinoids are the active ingredients of marijuana, which interact with cannabinoid receptors such as CNR1 and CNR2 to activate cellular signaling pathways. Human endometrium and placenta are known to express CNR1 and CNR2 and can respond to cannabinoid signaling. In this study, we show that marijuana use significantly increases mRNA or protein expression of CNR1 and CNR2 in human endometrium from the first and early second trimester pregnancies, with minor effects on placental expression of CNRs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
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Receptor CB1 de Canabinoide
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Receptor CB2 de Canabinoide
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Endométrio
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Uso da Maconha
Tipo de estudo:
Observational_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Placenta
Ano de publicação:
2018
Tipo de documento:
Article