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Differential Stiffening between the Abdominal and Thoracic Aorta: Effect of Salt Loading in Stroke-Prone Hypertensive Rats.
Lindesay, George; Bézie, Yvonnick; Ragonnet, Christophe; Duchatelle, Véronique; Dharmasena, Chandima; Villeneuve, Nicole; Vayssettes-Courchay, Christine.
Afiliação
  • Lindesay G; Cardiovascular Discovery Research Unit Suresnes, Servier Research Institute, Suresnes, France.
  • Bézie Y; Department of Pharmacy, Groupe Hospitalier Paris Saint-Joseph, Paris, France.
  • Ragonnet C; Cardiovascular Discovery Research Unit Suresnes, Servier Research Institute, Suresnes, France.
  • Duchatelle V; Department of Pathology, Groupe Hospitalier Paris Saint-Joseph, Paris, France.
  • Dharmasena C; Department of Pharmacy, Groupe Hospitalier Paris Saint-Joseph, Paris, France.
  • Villeneuve N; Cardiovascular Discovery Research Unit Suresnes, Servier Research Institute, Suresnes, France.
  • Vayssettes-Courchay C; Cardiovascular Discovery Research Unit Suresnes, Servier Research Institute, Suresnes, France.
J Vasc Res ; 55(3): 144-158, 2018.
Article em En | MEDLINE | ID: mdl-29886482
Central artery stiffening is recognized as a cardiovascular risk. The effects of hypertension and aging have been shown in human and animal models but the effect of salt is still controversial. We studied the effect of a high-salt diet on aortic stiffness in salt-sensitive spontaneously hypersensitive stroke-prone rats (SHRSP). Distensibility, distension, and ß-stiffness were measured at thoracic and abdominal aortic sites in the same rats, using echotracking recording of the aortic diameter coupled with blood pressure (BP), in SHRSP-salt (5% salted diet, 5 weeks), SHRSP, and normotensive Wistar-Kyoto (WKY) rats. Hemodynamic parameters were measured at BP matched to that of WKY. Histological staining and immunohistochemistry were used for structural analysis. Hemodynamic isobaric parameters in SHRSP did not differ from WKY and only those from the abdominal aorta of SHRSP-salt presented decreased distensibility and increased stiffness compared with WKY and SHRSP. The abdominal and thoracic aortas presented similar thickening, increased fibrosis, and remodeling with no change in collagen content. SHRSP-salt presented a specific increased elastin disarray at the abdominal aorta level but a decrease in elastin content in the thoracic aorta. This study demonstrates the pro-stiffening effect of salt in addition to hypertension; it shows that only the abdominal aorta presents a specific pressure-independent stiffening, in which elastin disarray is likely a key mechanism.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta Abdominal / Aorta Torácica / Cloreto de Sódio na Dieta / Rigidez Vascular / Pressão Arterial / Hipertensão Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: J Vasc Res Assunto da revista: ANGIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta Abdominal / Aorta Torácica / Cloreto de Sódio na Dieta / Rigidez Vascular / Pressão Arterial / Hipertensão Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: J Vasc Res Assunto da revista: ANGIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França País de publicação: Suíça