Prevalence of wild type ATTR assessed as myocardial uptake in bone scan in the elderly population.
Int J Cardiol
; 270: 192-196, 2018 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-29903517
ABSTRACT
BACKGROUND:
Myocardial uptake of bone tracers has emerged as useful tool for the early detection of transthyretin amyloidosis (ATTR). The prevalence of wild-type ATTR (ATTRwt) in individuals remains to be established.METHODS:
All whole body bone scans performed in individualsâ¯≥â¯75â¯years with no previous clinical suspicion of ATTR were revised in a population-based university hospital over a 7-year period (1509 studies corresponding to 1114 patients; 80.5⯱â¯4.1â¯years, 65% males). Positive cardiac uptake was defined according to Perugini score as grade 2 or 3. Heart failure (HF) hospitalizations during the follow-up were obtained from regional administrative databases.RESULTS:
Thirty-one patientsâ¯≥â¯75â¯years (2.78%) showed cardiac uptake; compared with those without uptake, these patients were older (85⯱â¯5 vs. 80⯱â¯4, pâ¯<â¯0.001) and predominantly males (90% vs. 64%, pâ¯=â¯0.005). The prevalence of cardiac uptake was 3.88% in males and 0.77% in females, and increased with age, reaching 13.9% in males≥85â¯years (2.7% among females). The estimated prevalence for the European standard populationâ¯≥â¯75â¯years was 4.15% in males, 1.03% in females and 2.59% in the general population. HF hospitalizations rates were 14% in patients without uptake and 29% in those with cardiac uptake (pâ¯=â¯0.034). After adjusting for age and gender, cardiac uptake was associated with a higher risk of HF hospitalization (OR 2.60, 95%CI 1.09-5.74, pâ¯=â¯0.022).CONCLUSIONS:
Myocardial uptake in bone scan is very prevalent with ageing, mainly affects males and is associated with an increased risk of HF hospitalization. These findings reinforce ATTRwt as a relevant cause of HF in the elderly.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cintilografia
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Vigilância da População
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Compostos Radiofarmacêuticos
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Neuropatias Amiloides Familiares
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Coração
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Int J Cardiol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Espanha