Dual role of ethyl bromodifluoroacetate in the formation of fluorine-containing heteroaromatic compounds.
Chem Commun (Camb)
; 54(65): 8960-8963, 2018 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-29932181
ABSTRACT
An efficient one-pot cascade process via unprecedented quadruple cleavage of BrCF2COOEt with primary amines to afford valuable fluorine-containing heterocycles is described, in which BrCF2COOEt plays a dual role as a C1 synthon and a difluoroalkylating reagent for the first time. Mechanistic studies supported by DFT calculations suggest that a base plays an active role in the formation of the key intermediate isocyanides generated in situ from primary amines and difluorocarbene.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2018
Tipo de documento:
Article