A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.

Sananes, Amiram; Cohen, Itay; Shahar, Anat; Hockla, Alexandra; De Vita, Elena; Miller, Aubry K; Radisky, Evette S; Papo, Niv

Sananes, Amiram; Cohen, Itay; Shahar, Anat; Hockla, Alexandra; De Vita, Elena; Miller, Aubry K; Radisky, Evette S; Papo, Niv.

Afiliação

Sananes A; Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, 84105 Israel.
Cohen I; Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, 84105 Israel.
Shahar A; The National Institute for Biotechnology in the Negev (NIBN), Beer-Sheva, 84105 Israel.
Hockla A; Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224.
De Vita E; Cancer Drug Development Group, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
Miller AK; Cancer Drug Development Group, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
Radisky ES; Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224.
Papo N; Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, 84105 Israel. Electronic address: papo@bgu.ac.il.

J Biol Chem ; 293(33): 12663-12680, 2018 08 17.

Article em En | MEDLINE | ID: mdl-29934309

Assuntos

Precursor de Proteína beta-Amiloide/farmacologia; Neoplasias da Mama/tratamento farmacológico; Engenharia Genética; Calicreínas/antagonistas & inibidores; Inibidores de Proteases/farmacologia; Proteólise; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Movimento Celular; Proliferação de Células; Feminino; Ensaios de Triagem em Larga Escala; Humanos; Calicreínas/química; Modelos Moleculares; Ligação Proteica; Conformação Proteica; Células Tumorais Cultivadas

Palavras-chave

X-ray crystallography; cell invasion; directed evolution; enzyme inhibition; protease inhibitor; protein engineering; proteolysis; selective binding; yeast surface display

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Neoplasias da Mama / Calicreínas / Engenharia Genética / Precursor de Proteína beta-Amiloide / Proteólise Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2018 Tipo de documento: Article

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