Targeted resequencing of a locus for heparin-induced thrombocytopenia on chromosome 5 identified in a genome-wide association study.

Witten, Anika; Bolbrinker, Juliane; Barysenka, Andrei; Huber, Matthias; Rühle, Frank; Nowak-Göttl, Ulrike; Garbe, Edeltraut; Kreutz, Reinhold; Stoll, Monika

Witten, Anika; Bolbrinker, Juliane; Barysenka, Andrei; Huber, Matthias; Rühle, Frank; Nowak-Göttl, Ulrike; Garbe, Edeltraut; Kreutz, Reinhold; Stoll, Monika.

Afiliação

Witten A; Department of Genetic Epidemiology, Institute of Human Genetics, University Hospital Münster, Münster, Germany.
Bolbrinker J; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany.
Barysenka A; Department of Genetic Epidemiology, Institute of Human Genetics, University Hospital Münster, Münster, Germany.
Huber M; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany.
Rühle F; Department of Genetic Epidemiology, Institute of Human Genetics, University Hospital Münster, Münster, Germany.
Nowak-Göttl U; Thrombosis and Hemostasis Unit, Department of Clinical Chemistry, University Hospital of Kiel and Lübeck, Kiel, Germany.
Garbe E; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany.
Kreutz R; Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
Stoll M; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany.

J Mol Med (Berl) ; 96(8): 765-775, 2018 08.

Article em En | MEDLINE | ID: mdl-29934777

Assuntos

Anticoagulantes/efeitos adversos; Cromossomos Humanos Par 5; Predisposição Genética para Doença; Heparina/efeitos adversos; Locos de Características Quantitativas; Trombocitopenia/etiologia; Idoso; Alelos; Biomarcadores; Estudos de Casos e Controles; Feminino; Estudo de Associação Genômica Ampla; Genótipo; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Masculino; Pessoa de Meia-Idade; Razão de Chances; Testes Farmacogenômicos; Polimorfismo de Nucleotídeo Único; Trombocitopenia/sangue; Trombocitopenia/diagnóstico

Palavras-chave

ADAMTS16; ADR; GWAS; HIT; ICE1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombocitopenia / Cromossomos Humanos Par 5 / Heparina / Predisposição Genética para Doença / Locos de Características Quantitativas / Anticoagulantes Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Mol Med (Berl) Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Alemanha

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