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Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase.
Blaquiere, Nicole; Castanedo, Georgette M; Burch, Jason D; Berezhkovskiy, Leonid M; Brightbill, Hans; Brown, Suzanne; Chan, Connie; Chiang, Po-Chang; Crawford, James J; Dong, Teresa; Fan, Peter; Feng, Jianwen; Ghilardi, Nico; Godemann, Robert; Gogol, Emily; Grabbe, Alice; Hole, Alison J; Hu, Baihua; Hymowitz, Sarah G; Alaoui Ismaili, Moulay Hicham; Le, Hoa; Lee, Patrick; Lee, Wyne; Lin, Xingyu; Liu, Ning; McEwan, Paul A; McKenzie, Brent; Silvestre, Hernani L; Suto, Eric; Sujatha-Bhaskar, Swathi; Wu, Guosheng; Wu, Lawren C; Zhang, Yamin; Zhong, Zoe; Staben, Steven T.
Afiliação
  • Blaquiere N; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Castanedo GM; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Burch JD; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Berezhkovskiy LM; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Brightbill H; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Brown S; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Chan C; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Chiang PC; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Crawford JJ; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Dong T; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Fan P; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Feng J; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Ghilardi N; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Godemann R; Evotec AG , Manfred Eigen Campus, Essener Bogen , Hamburg 22419 , Germany.
  • Gogol E; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Grabbe A; Evotec AG , Manfred Eigen Campus, Essener Bogen , Hamburg 22419 , Germany.
  • Hole AJ; Evotec AG , Manfred Eigen Campus, Essener Bogen , Hamburg 22419 , Germany.
  • Hu B; Pharmaron Beijing Co., Ltd. , 6 Taihe Road, BDA , Beijing 100176 , P. R. China.
  • Hymowitz SG; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Alaoui Ismaili MH; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Le H; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Lee P; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Lee W; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Lin X; Pharmaron Beijing Co., Ltd. , 6 Taihe Road, BDA , Beijing 100176 , P. R. China.
  • Liu N; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • McEwan PA; Evotec AG , Manfred Eigen Campus, Essener Bogen , Hamburg 22419 , Germany.
  • McKenzie B; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Silvestre HL; Evotec AG , Manfred Eigen Campus, Essener Bogen , Hamburg 22419 , Germany.
  • Suto E; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Sujatha-Bhaskar S; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Wu G; Pharmaron Beijing Co., Ltd. , 6 Taihe Road, BDA , Beijing 100176 , P. R. China.
  • Wu LC; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Zhang Y; Pharmaron Beijing Co., Ltd. , 6 Taihe Road, BDA , Beijing 100176 , P. R. China.
  • Zhong Z; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Staben ST; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
J Med Chem ; 61(15): 6801-6813, 2018 08 09.
Article em En | MEDLINE | ID: mdl-29940120
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Inibidores de Proteínas Quinases / Descoberta de Drogas Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Inibidores de Proteínas Quinases / Descoberta de Drogas Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos