Illuminating GPCR Signaling by Cryo-EM.

Safdari, Haaris Ahsan; Pandey, Shubhi; Shukla, Arun K; Dutta, Somnath

Safdari, Haaris Ahsan; Pandey, Shubhi; Shukla, Arun K; Dutta, Somnath.

Afiliação

Safdari HA; Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India.
Pandey S; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India.
Shukla AK; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India. Electronic address: arshukla@iitk.ac.in.
Dutta S; Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India. Electronic address: somnath@iisc.ac.in.

Trends Cell Biol ; 28(8): 591-594, 2018 08.

Article em En | MEDLINE | ID: mdl-29945844

RESUMO

The wave of resolution revolution in cryo-EM has touched, and made a significant impact on, the structural biology of GPCRs. High-resolution structures of several GPCR-G-protein complexes are now determined by cryo-EM and they illuminate fine structural details of this central macromolecular complex involved in cellular signaling.

Assuntos

Receptores Acoplados a Proteínas G/metabolismo; Transdução de Sinais; Microscopia Crioeletrônica; Humanos; Receptores Acoplados a Proteínas G/química

Palavras-chave

GPCR; arrestins; biased signaling; cryo-EM; negative-staining

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Receptores Acoplados a Proteínas G Limite: Humans Idioma: En Revista: Trends Cell Biol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Índia País de publicação: Reino Unido

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