The role of nCD64 in the diagnosis of neonatal sepsis in preterm newborns.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
; 2018 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-29955185
ABSTRACT
BACKGROUND:
Diagnosing neonatal sepsis is difficult, particularly in preterm newborns. A promising method appears to be evaluation of cell surface markers by flow cytometry.METHODS:
This prospective study investigated 217 newborns suspected of having early- or late-onset neonatal sepsis. In all, flow cytometry was used to determine the proportion of CD64-positive neutrophils (nCD64). Based on the clinical course and laboratory test results, newborns were categorized as having proven, possible, clinical or no neonatal sepsis. Subsequently, associations between the categories and nCD64 values were analyzed.RESULTS:
There were significant associations between nCD64 values and the development of sepsis in newborns with both early- or late-onset sepsis.CONCLUSION:
nCD64expression is significantly elevated in preterm newborn with early and late onset sepsis. The results show that nCD64 is a reliable marker for diagnosing neonatal sepsis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
Assunto da revista:
MEDICINA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
República Tcheca