Regiospecific N-Arylation of Aliphatic Amines under Mild and Metal-Free Reaction Conditions.
Angew Chem Int Ed Engl
; 57(35): 11427-11431, 2018 Aug 27.
Article
em En
| MEDLINE
| ID: mdl-29956877
ABSTRACT
A transition metal-free N-arylation of primary and secondary amines with diaryliodonium salts is presented. Both acyclic and cyclic amines are well tolerated, providing a large set of N-alkyl anilines. The methodology is unprecedented among metal-free methods in terms of amine scope, the ability to transfer both electron-withdrawing and electron-donating aryl groups, and efficient use of resources, as excess substrate or reagents are not required.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Suécia