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Coverage of Haemophilus influenzae Type b Conjugate Vaccine for Children in Mainland China: Systematic Review and Meta-analysis.
Yang, Ya; Yang, Yu; Scherpbier, Robert W; Zhu, Xu; Chen, Yue; Zhou, Yibiao; Jiang, Qingwu.
Afiliação
  • Yang Y; From the Key Laboratory of Public Health Safety, Ministry of Education, China.
  • Yang Y; Tropical Disease Research Center, Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
  • Scherpbier RW; From the Key Laboratory of Public Health Safety, Ministry of Education, China.
  • Zhu X; Tropical Disease Research Center, Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China.
  • Chen Y; UNICEF Beijing Office, Beijing, China.
  • Zhou Y; UNICEF Beijing Office, Beijing, China.
  • Jiang Q; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Pediatr Infect Dis J ; 38(3): 248-252, 2019 03.
Article em En | MEDLINE | ID: mdl-29957731
BACKGROUND: Use of Haemophilus influenzae type b conjugate vaccine is effective in reducing the disease burden, but its coverage in China is unclear. The aim of this meta-analysis is to assess the coverage of Hib conjugate vaccines in children in Mainland China. METHODS: We systematically searched Pubmed, Web of Science, Medline, CNKI and Wanfang to identify studies assessing the coverage of Hib vaccine in Chinese children. Random-effects models were used to obtain pooled estimates for Hib vaccine coverage and analyzed heterogeneity with meta-regression and subgroup analyses. RESULTS: Thirty-three studies that included 7,227,480 subjects in 12 provinces met our inclusion criteria. The pooled overall coverage of Hib conjugate vaccine was 54.9% [95% confidence interval (CI): 52.9-57.0]. The pooled coverage for the nonlocal population (54.3%; 95% CI: 52.4-56.3) was lower than that for the local residents (62.0%; 95% CI: 58.4-65.6). The region-pooled coverage was higher in the east of China (59.7%; 95% CI: 57.3-62.1) than in the central and west parts of the country (48.5%; 95% CI: 40.6-56.4). Overall, 26.7% (95% CI: 20.1-33.2) had 1 dose only, 14.8% (95% CI: 10.0-19.6%) had 2 doses, 13.5% (95% CI: 9.1-17.8) had 3 doses and 14.3% (95% CI: 9.7-18.9) had 4 doses. CONCLUSIONS: We found a low coverage of Hib conjugate vaccine, particularly for the nonlocal children and those living in the central and west parts of China. Including Hib vaccine into the national immunization program is recommended to reduce disparities in vaccination coverage.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Programas de Imunização / Vacinas Anti-Haemophilus / Cobertura Vacinal / Infecções por Haemophilus Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Child / Humans País/Região como assunto: Asia Idioma: En Revista: Pediatr Infect Dis J Assunto da revista: DOENCAS TRANSMISSIVEIS / PEDIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Programas de Imunização / Vacinas Anti-Haemophilus / Cobertura Vacinal / Infecções por Haemophilus Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Child / Humans País/Região como assunto: Asia Idioma: En Revista: Pediatr Infect Dis J Assunto da revista: DOENCAS TRANSMISSIVEIS / PEDIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos