Platelet lysate promotes re-epithelialization of persistent epithelial defects: a pilot study.
Int Ophthalmol
; 39(7): 1483-1490, 2019 Jul.
Article
em En
| MEDLINE
| ID: mdl-29978342
ABSTRACT
PURPOSE:
To study the use of autologous platelet lysate prepared in a standardized method for the healing of persistent corneal epithelial defects (PED). STUDYDESIGN:
Clinical and experimental investigation.METHODS:
In this prospective pilot study (ClinicalTrials.gov identifier NCT02979912), ten patients with a PED duration of a minimum 14 days were included. Autologous platelet lysate was prepared in a standardized methodology. Repeated freeze-thaw cycles were used to lyse the platelets. Patients were advised to apply the eye drops four times a day and were evaluated at baseline and on days 7, 14, 21, 28.RESULTS:
No adverse events were reported due to the use of undiluted autologous platelet lysate. A total of 70% of patients had complete re-epithelialization within 28 days. Of these, 40% healed within 14 days (effective group) and 30% within 28 days (partially effective group).CONCLUSIONS:
Undiluted autologous platelet lysate, prepared according to a standardized methodology, is a safe and effective adjunct therapy for the treatment of PED.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Epitélio Corneano
/
Doenças da Córnea
/
Reepitelização
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int Ophthalmol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Jordânia