A prospective study of inflammatory biomarker levels and risk of early menopause.
Menopause
; 26(1): 32-38, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-29994968
ABSTRACT
OBJECTIVE:
Early menopause, the cessation of ovarian function before age 45, has consequences for fertility and cardiovascular health. Evidence from studies of women with autoimmune conditions and genetic studies supports a role for inflammation in early menopause, but the association of inflammatory markers and risk has not been directly evaluated.METHODS:
We assessed the relation of the soluble fraction of tumor necrosis factor alpha receptor 2 (sTNFR2), C-reactive protein, interleukin-6 (IL6) levels with incident early menopause among Nurses' Health Study II participants who provided a premenopausal blood sample in 1996 to 1999. Cases (nâ=â328) were women reporting natural menopause between blood collection and age 45.Controls (nâ=â492) included (1) 328 women with menopause after age 47, matched 11 with cases on age at blood collection and other factors; and (2) 164 additional women with menopause after age 45.RESULTS:
In multivariable models comparing cases and nâ=â492 controls, we observed a significant association of sTNFR2 levels and risk of early menopause (Pâ=â0.002). Compared with women with the lowest sTNFR2 levels, odds ratios (95% CIs) for quartiles 2 to 4 were 0.60 (0.38-0.95), 0.93 (0.61-1.43), and 1.40 (0.93-2.11). Results further adjusting for antimüllerian hormone levels were similar in magnitude, as were results from sensitivity analyses of matched cases and controls (nâ=â328 pairs), nonsmokers, and leaner women. C-reactive protein and IL6 levels were unrelated to risk.CONCLUSIONS:
The observation of lower risk of early menopause among women with moderate sTNFR2 levels compared with women with lower and higher levels warrants further prospective study.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Menopausa Precoce
/
Mediadores da Inflamação
/
Receptores Tipo II do Fator de Necrose Tumoral
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
Menopause
Assunto da revista:
GINECOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Marrocos