Choroid plexus Na+/K+-activated adenosine triphosphatase and cerebrospinal fluid formation.
Neurosurgery
; 17(5): 768-72, 1985 Nov.
Article
em En
| MEDLINE
| ID: mdl-2999636
ABSTRACT
The quantitative relationship between intraventricular fluid formation and choroid plexus Na+/K+-activated (transport) adenosine triphosphatase (ATPase) was studied in rabbit and dog by perfusing the ventricular system with a solution containing ouabain (10(-8) to 10(-3) M). The effect of ouabain in the same range of concentrations on ATPase activity was also measured by the release of inorganic orthophosphate from in vitro choroid plexus tissue. Normally, about 20 to 25% of ATPase activity in lateral ventricle plexus is Na+/K+-activated, and this component is almost completely inhibited by ouabain in a concentration of 10(-4) M. At this concentration, the rate of intraventricular cerebrospinal fluid (CSF) formation is decreased some 70 to 80% in dog and rabbit. The results of this study suggest that a portion of the intraventricular fluid formation is insensitive to cardiac glycoside inhibition and that either there are two different mechanisms responsible for choroid plexus fluid formation or there is a significant non-ATPase dependent extrachoroidal source of CSF.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Líquido Cefalorraquidiano
/
Plexo Corióideo
/
ATPase Trocadora de Sódio-Potássio
Limite:
Animals
Idioma:
En
Revista:
Neurosurgery
Ano de publicação:
1985
Tipo de documento:
Article