[Research advances in the v-raf murine sarcoma viral oncogene homolog gene mutation in ameloblastoma].
Zhonghua Kou Qiang Yi Xue Za Zhi
; 53(7): 500-502, 2018 Jul 09.
Article
em Zh
| MEDLINE
| ID: mdl-29996373
ABSTRACT
V-raf murine sarcoma viral oncogene homolog B1 (BRAF) is a pro-oncogene, which is one member of the RAF family. Mutated BRAF is found in approximately 8% of human tumors. BRAF gene mutations lead to continuous activation of the mitogen-activatd protein kinase (MAPK) pathway, which resulting in abnormal cell proliferation and tumorigenesis. In recent years, recurrent MAPK signaling mutations were identified in ameloblastoma, among which BRAF-V600E is the most prominent type. This provides new strategies for the targeted treatment of ameloblastoma. This paper reviewed the latest advances in BRAF gene mutation associated with ameloblastoma and its potential clinical significance.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ameloblastoma
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Neoplasias Maxilomandibulares
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Proteínas Proto-Oncogênicas B-raf
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Mutação
Limite:
Animals
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Humans
Idioma:
Zh
Revista:
Zhonghua Kou Qiang Yi Xue Za Zhi
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China