Design, synthesis and biological evaluation of 3-piperazinecarboxylate sarsasapogenin derivatives as potential multifunctional anti-Alzheimer agents.

Yang, Gui-Xiang; Ge, Song-Lan; Wu, Yan; Huang, Jin; Li, Shi-Liang; Wang, Rui; Ma, Lei

Yang, Gui-Xiang; Ge, Song-Lan; Wu, Yan; Huang, Jin; Li, Shi-Liang; Wang, Rui; Ma, Lei.

Afiliação

Yang GX; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Ge SL; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Wu Y; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Huang J; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Li SL; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China. Electronic address: slli403@163.com.
Wang R; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China. Electronic address: ruiwang@ecust.edu.cn.
Ma L; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China. Electronic address: malei@ecust.edu.cn.

Eur J Med Chem ; 156: 206-215, 2018 Aug 05.

Article em En | MEDLINE | ID: mdl-30006165

Assuntos

Doença de Alzheimer/tratamento farmacológico; Peptídeos beta-Amiloides/metabolismo; Desenho de Fármacos; Fragmentos de Peptídeos/metabolismo; Espirostanos/química; Espirostanos/farmacologia; Doença de Alzheimer/metabolismo; Animais; Anti-Inflamatórios/química; Anti-Inflamatórios/farmacologia; Antioxidantes/química; Antioxidantes/farmacologia; Humanos; Camundongos; Simulação de Acoplamento Molecular; Fármacos Neuroprotetores/química; Fármacos Neuroprotetores/farmacologia; Células PC12; Piperazinas/química; Piperazinas/farmacologia; Agregados Proteicos/efeitos dos fármacos; Células RAW 264.7; Ratos

Palavras-chave

Alzheimer's disease; Antiinflammation; Antioxidation; Beta-amyloid; Sarsasapogenin derivatives; Structure-activity relationship

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Espirostanos / Desenho de Fármacos / Peptídeos beta-Amiloides / Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2018 Tipo de documento: Article País de publicação: França

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