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Myelin Protein Zero180-199 Peptide Induced Experimental Autoimmune Neuritis in C57BL/6 Mice.
Gonsalvez, David G; Yoo, SangWon; Craig, Georgina A; Wood, Rhiannon J; Fletcher, Jessica L; Murray, Simon S; Xiao, Junhua.
Afiliação
  • Gonsalvez DG; Faculty of Medicine, Dentistry and Health Sciences, Department of Anatomy and Neuroscience, School of Biomedical Sciences, The University of Melbourne, Melbourne, VIC, Australia.
  • Yoo S; Faculty of Medicine, Dentistry and Health Sciences, Department of Anatomy and Neuroscience, School of Biomedical Sciences, The University of Melbourne, Melbourne, VIC, Australia.
  • Craig GA; Faculty of Medicine, Dentistry and Health Sciences, Department of Anatomy and Neuroscience, School of Biomedical Sciences, The University of Melbourne, Melbourne, VIC, Australia.
  • Wood RJ; Faculty of Medicine, Dentistry and Health Sciences, Department of Anatomy and Neuroscience, School of Biomedical Sciences, The University of Melbourne, Melbourne, VIC, Australia.
  • Fletcher JL; Faculty of Medicine, Dentistry and Health Sciences, Department of Anatomy and Neuroscience, School of Biomedical Sciences, The University of Melbourne, Melbourne, VIC, Australia.
  • Murray SS; Faculty of Medicine, Dentistry and Health Sciences, Department of Anatomy and Neuroscience, School of Biomedical Sciences, The University of Melbourne, Melbourne, VIC, Australia.
  • Xiao J; Faculty of Medicine, Dentistry and Health Sciences, Department of Anatomy and Neuroscience, School of Biomedical Sciences, The University of Melbourne, Melbourne, VIC, Australia. xiaoj@unimelb.edu.au.
Methods Mol Biol ; 1791: 243-250, 2018.
Article em En | MEDLINE | ID: mdl-30006715
Mouse models of peripheral demyelinating neuropathy play an important role in enabling the study of disease pathogenesis. Further, induction in transgenic mice allows for the precise interrogation of disease mechanisms, as well as the analysis of the efficacy and mechanisms of potential new therapies. Here we describe a method to successfully induce experimental autoimmune neuritis (EAN) using myelin protein zero (P0)180-199 peptide in combination with Freund's complete adjuvant and pertussis toxin in the C57BL/6 mouse strain. We also outline a sensitive paradigm of accurately assessing the extent of functional deficits occurring in murine EAN.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Proteína P0 da Mielina / Neurite Autoimune Experimental Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Methods Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Austrália País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Proteína P0 da Mielina / Neurite Autoimune Experimental Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Methods Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Austrália País de publicação: Estados Unidos