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Small molecule disruption of G protein ßγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats.
Karuppagounder, Vengadeshprabhu; Bajpai, Anamika; Meng, Shu; Arumugam, Somasundaram; Sreedhar, Remya; Giridharan, Vijayasree V; Guha, Ashrith; Bhimaraj, Arvind; Youker, Keith A; Palaniyandi, Suresh S; Karmouty-Quintana, Harry; Kamal, Fadia; Spiller, Kara L; Watanabe, Kenichi; Thandavarayan, Rajarajan A.
Afiliação
  • Karuppagounder V; Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
  • Bajpai A; Department of Orthopaedic and Rehabilitation, Penn State college of medicine, Hershey, Pennsylvania, United States of America.
  • Meng S; Biomaterials and Regenerative Medicine Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania, United States of America.
  • Arumugam S; Department of Biochemistry and Molecular Biology, Houston Medical School, University of Texas, Houston, United States of America.
  • Sreedhar R; Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
  • Giridharan VV; Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
  • Guha A; Department of Psychiatry and Behavioral Sciences, Translational Psychiatry Program, McGovern Medical School, Houston, Texas, United States of America.
  • Bhimaraj A; Houston Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas, United States of America.
  • Youker KA; Houston Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas, United States of America.
  • Palaniyandi SS; Houston Methodist DeBakey Heart and Vascular Center, Houston Methodist Hospital, Houston, Texas, United States of America.
  • Karmouty-Quintana H; Division of Hypertension and Vascular Research, Henry Ford Health System, Detroit, Michigan, United States of America.
  • Kamal F; Department of Biochemistry and Molecular Biology, Houston Medical School, University of Texas, Houston, United States of America.
  • Spiller KL; Department of Orthopaedic and Rehabilitation, Penn State college of medicine, Hershey, Pennsylvania, United States of America.
  • Watanabe K; Biomaterials and Regenerative Medicine Laboratory, School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, Pennsylvania, United States of America.
  • Thandavarayan RA; Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.
PLoS One ; 13(7): e0200697, 2018.
Article em En | MEDLINE | ID: mdl-30024944
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Xantenos / Transdução de Sinais / Subunidades beta da Proteína de Ligação ao GTP / Subunidades gama da Proteína de Ligação ao GTP / Macrófagos / Miocardite Limite: Animals / Humans / Male Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Xantenos / Transdução de Sinais / Subunidades beta da Proteína de Ligação ao GTP / Subunidades gama da Proteína de Ligação ao GTP / Macrófagos / Miocardite Limite: Animals / Humans / Male Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão País de publicação: Estados Unidos