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Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells.
Grevet, Jeremy D; Lan, Xianjiang; Hamagami, Nicole; Edwards, Christopher R; Sankaranarayanan, Laavanya; Ji, Xinjun; Bhardwaj, Saurabh K; Face, Carolyne J; Posocco, David F; Abdulmalik, Osheiza; Keller, Cheryl A; Giardine, Belinda; Sidoli, Simone; Garcia, Ben A; Chou, Stella T; Liebhaber, Stephen A; Hardison, Ross C; Shi, Junwei; Blobel, Gerd A.
Afiliação
  • Grevet JD; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Lan X; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Hamagami N; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Edwards CR; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Sankaranarayanan L; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Ji X; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Bhardwaj SK; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Face CJ; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Posocco DF; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Abdulmalik O; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Keller CA; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Giardine B; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
  • Sidoli S; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
  • Garcia BA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Chou ST; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Liebhaber SA; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  • Hardison RC; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Shi J; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.
  • Blobel GA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. jushi@upenn.edu blobel@email.chop.edu.
Science ; 361(6399): 285-290, 2018 07 20.
Article em En | MEDLINE | ID: mdl-30026227
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobina Fetal / Proteínas Nucleares / Proteínas de Transporte / Regulação da Expressão Gênica / EIF-2 Quinase / Células Eritroides / Anemia Falciforme Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Science Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobina Fetal / Proteínas Nucleares / Proteínas de Transporte / Regulação da Expressão Gênica / EIF-2 Quinase / Células Eritroides / Anemia Falciforme Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Science Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos