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Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors.
Talapatra, Sandeep K; Tham, Chuin Lean; Guglielmi, Paolo; Cirilli, Roberto; Chandrasekaran, Balakumar; Karpoormath, Rajshekhar; Carradori, Simone; Kozielski, Frank.
Afiliação
  • Talapatra SK; School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, United Kingdom.
  • Tham CL; School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, United Kingdom.
  • Guglielmi P; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185, Rome, Italy.
  • Cirilli R; National Institute of Health, Centre for the Control and Evaluation of Medicines, Viale Regina Elena 299, 00161, Rome, Italy.
  • Chandrasekaran B; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (UKZN), Westville, Durban, 4001, South Africa.
  • Karpoormath R; Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (UKZN), Westville, Durban, 4001, South Africa.
  • Carradori S; Department of Pharmacy, G. D'Annunzio University of Chieti/Pescara, Via Dei Vestini 31, 66100, Chieti, Italy.
  • Kozielski F; School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, United Kingdom. Electronic address: f.kozielski@ucl.ac.uk.
Eur J Med Chem ; 156: 641-651, 2018 Aug 05.
Article em En | MEDLINE | ID: mdl-30031975
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiadiazóis / Desenho de Fármacos / Cinesinas / Inibidores Enzimáticos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiadiazóis / Desenho de Fármacos / Cinesinas / Inibidores Enzimáticos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido