Urine miR-21-5p as a potential biomarker for predicting effectiveness of tadalafil in benign prostatic hyperplasia.
Future Sci OA
; 4(6): FSO304, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-30057782
ABSTRACT
AIM:
To investigate whether urine levels of miRNAs that regulate the function of endothelial cells are associated with effectiveness in benign prostatic hyperplasia (BPH) patients treated with a phosphodiesterase type 5 inhibitor, tadalafil. PATIENTS &METHODS:
We measured urine levels of three miRNAs (miR-21-5p, miR-126-5p & miR-155-5p) in 55 BPH patients before and after tadalafil administration to understand its effectiveness.RESULTS:
Baseline urine miR-21-5p level was an independent predictor of response to tadalafil in multivariate regression analysis (odds ratio 0.28; 95% CI 0.10-0.77; p = 0.014). Receiver operator curve analysis revealed that baseline urine miR-21-5p could serve as a predictor of response (area under curve 0.85; 95% CI 0.75-0.95; p < 0.001).CONCLUSION:
Urine miR-21-5p could serve as a biomarker in predicting response of tadalafil for BPH.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Future Sci OA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Japão