Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q<sup>58</sup>â»K<sup>59</sup> Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities.

Sikorra, Stefan; Skiba, Martin; Dorner, Martin B; Weisemann, Jasmin; Weil, Mirjam; Valdezate, Sylvia; Davletov, Bazbek; Rummel, Andreas; Dorner, Brigitte G; Binz, Thomas

Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q⁵⁸â»K⁵⁹ Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities.

Sikorra, Stefan; Skiba, Martin; Dorner, Martin B; Weisemann, Jasmin; Weil, Mirjam; Valdezate, Sylvia; Davletov, Bazbek; Rummel, Andreas; Dorner, Brigitte G; Binz, Thomas.

Afiliação

Sikorra S; Institute of Cell Biochemistry, OE 4310, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany. S.Sikorra@kabelmail.de.
Skiba M; Biological Toxins (ZBS 3), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, 13353 Berlin, Germany. SkibaM@rki.de.
Dorner MB; Biological Toxins (ZBS 3), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, 13353 Berlin, Germany. DornerM@rki.de.
Weisemann J; Institute of Toxicology, OE 5340, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany. Weisemann.Jasmin@mh-hannover.de.
Weil M; Biological Toxins (ZBS 3), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, 13353 Berlin, Germany. miri.weil@gmx.de.
Valdezate S; Reference and Research Laboratory for Taxonomy, Spanish National Centre of Microbiology, Institute of Health Carlos III, 28220 Madrid, Spain. svaldezate@isciii.es.
Davletov B; Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK. b.davletov@sheffield.ac.uk.
Rummel A; Institute of Toxicology, OE 5340, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany. Rummel.Andreas@mh-hannover.de.
Dorner BG; Biological Toxins (ZBS 3), Centre for Biological Threats and Special Pathogens, Robert Koch Institute, 13353 Berlin, Germany. dornerb@rki.de.
Binz T; Institute of Cell Biochemistry, OE 4310, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany. binz.thomas@mh-hannover.de.

Toxins (Basel) ; 10(8)2018 08 01.

Article em En | MEDLINE | ID: mdl-30071628

Assuntos

Toxinas Botulínicas/química; Peptídeos/química; Proteína 2 Associada à Membrana da Vesícula/química; Catálise; Especificidade por Substrato

Palavras-chave

Clostridium botulinum; Zn2+ protease; botulinum neurotoxin; serotype F; subtype; synaptobrevin; vesicle associated membrane protein 2 (VAMP-2)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Toxinas Botulínicas / Proteína 2 Associada à Membrana da Vesícula Tipo de estudo: Prognostic_studies Idioma: En Revista: Toxins (Basel) Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Suíça

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