A stereological study of the effects of mercury inhalation on the cerebellum.
Biotech Histochem
; 94(1): 42-47, 2019 Jan.
Article
em En
| MEDLINE
| ID: mdl-30079771
ABSTRACT
Mercury in the environment that arises from organic and inorganic sources can cause irreversible damage to the nervous system. Toxicity may be direct or may arise from interactions with other metals in the environment. We evaluated the possible effects of mercury vapor on rat cerebellum. Twelve adult female rats were divided into control and experimental groups. The rats in the experimental group were exposed to mercury vapor for 9 h/day for 45 days. Cerebellar tissue samples were evaluated using stereology and for histopathology. The total number of Purkinje cells was estimated using a physical disector method. We found that in the experimental group, overall volume decreased and the number of Purkinje cells was reduced. We also found cellular damage including pycnotic nuclei, eosinophilic cytoplasm and vacuolization; these features were absent in the control group. We found that chronic exposure to inorganic mercury vapor is toxic to the cerebellum.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cerebelo
/
Mercúrio
Limite:
Animals
Idioma:
En
Revista:
Biotech Histochem
Assunto da revista:
HISTOCITOQUIMICA
Ano de publicação:
2019
Tipo de documento:
Article