Abnormalities of thalamus volume and resting state functional connectivity in primary insomnia patients.
Brain Imaging Behav
; 13(5): 1193-1201, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-30091019
ABSTRACT
Primary insomnia (PI) is associated with deteriorating attention, memory, physical and mood complaints. Based on the extensive literature demonstrating the critical roles of the thalamus in sleep regulation, we hypothesized that insomnia would be associated with functional and structural changes of the thalamus. This information is needed to better understand the neural mechanisms of insomnia, and would be useful for informing future attempts to alleviate or treat insomnia symptoms. Twenty-seven PI patients and 39 matched healthy controls were included in the present study. Subcortical volume and resting state functional connectivity (RSFC) of thalamus were compared between groups, and the relationships between neuroimaging differences and clinical features, including the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index Scale (ISI), the Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS), also be explored. Compared with the control group, the PI group showed significantly reduced volume of thalamus. In addition, several brain regions showed reduced RSFC with thalamus in PI patients, such as anterior cingulate cortex (ACC), orbitofrontal cortex, hippocampus, caudate and putamen. Correlation analyses revealed that, several of these RSFC patterns were negatively correlated with PSQI score among PI patients, including thalamic connections with the putamen, caudate, hippocampus. Negative correlation was also observed between the RSFC strength of right thalamus-right ACC and SDS score in PI patients. This work demonstrates the structural and functional abnormalities of the thalamus in PI patients that were associated with key clinical features of insomnia. These data further highlight the important role of the thalamus in sleep and PI.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tálamo
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Mapeamento Encefálico
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Imageamento por Ressonância Magnética
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Distúrbios do Início e da Manutenção do Sono
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Brain Imaging Behav
Assunto da revista:
CEREBRO
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CIENCIAS DO COMPORTAMENTO
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DIAGNOSTICO POR IMAGEM
Ano de publicação:
2019
Tipo de documento:
Article