Imaging mass spectrometry for toxicity assessment: a useful technique to confirm drug distribution in histologically confirmed lesions.

Kashimura, Akane; Tanaka, Kouji; Sato, Hiroko; Kaji, Hidefumi; Tanaka, Masaharu

Kashimura, Akane; Tanaka, Kouji; Sato, Hiroko; Kaji, Hidefumi; Tanaka, Masaharu.

Afiliação

Kashimura A; Safety Research Laboratories, Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50 Kawagishi, Toda-shi, Saitama 335-8505, Japan.
Tanaka K; DMPK Research Laboratories, Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50 Kawagishi, Toda-shi, Saitama 335-8505, Japan.
Sato H; Safety Research Laboratories, Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50 Kawagishi, Toda-shi, Saitama 335-8505, Japan.
Kaji H; Advanced Medical Business Development Department, Drug Development Service Segment, LSI Medience Corporation, 1-13-4 Uchikanda, Chiyoda-ku, Tokyo 101-8517, Japan.
Tanaka M; Safety Research Laboratories, Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 2-2-50 Kawagishi, Toda-shi, Saitama 335-8505, Japan.

J Toxicol Pathol ; 31(3): 221-227, 2018 Jul.

Article em En | MEDLINE | ID: mdl-30093793

Palavras-chave

amiodarone; desethylamiodarone; histological examination; imaging mass spectrometry; phosphatidylcholines; toxicity assessment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Toxicol Pathol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Japão País de publicação: Japão

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