The effect of zolpidem on cognitive function and postural control at high altitude.
Sleep
; 41(10)2018 10 01.
Article
em En
| MEDLINE
| ID: mdl-30099547
ABSTRACT
Study Objectives:
Sleep is altered at high altitude leading many mountaineers to use hypnotics in order to improve sleep efficiency. While after a full night at altitude the short-acting hypnotic zolpidem does not appear to alter cognitive function, residual adverse effects should be considered following early waking-up as performed by mountaineers. We hypothesized that zolpidem intake at high altitude would alter cognitive function 4 hours after drug intake.Methods:
In a randomized double-blind controlled cross-over study, 22 participants were evaluated during two nights at sea level and two nights at 3800 m, 4 hours after zolpidem (10 mg) or placebo intake at 1000 pm. Polygraphic recording was performed until waking-up at 0130 am. Sleep quality, sleepiness and symptoms of acute mountain sickness were assessed by questionnaires. Two cognitive tasks (Simon task and duration-production task) were performed at rest and during exercise and postural control was evaluated.Results:
Zolpidem increased reaction time in all conditions (zolpidem 407 ± 9 ms vs. placebo 380 ± 11 ms; p < 0.001) and error rate in incongruent trials only (10.2 ± 1.1% vs. 7.8 ± 0.8%; p < 0.01) in the Simon task and increased time perception variability (p < 0.001). Zolpidem also altered postural parameters (e.g. center of pressure area, zolpidem 236 ± 171.5 mm2 vs. placebo 119.6 ± 59 mm2; p < 0.001). Zolpidem did not affect apnea-hypopnea index and mean arterial oxygen saturation (p > 0.05) but increased sleep quality (p < 0.001). Zolpidem increased symptoms of acute mountain sickness and sleepiness (p < 0.05).Conclusions:
Acute zolpidem intake at high altitude alters cognitive functions and postural control during early wakening which may be deleterious for safety and performances of climbers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Postura
/
Cognição
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Altitude
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Medicamentos Indutores do Sono
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Zolpidem
/
Distúrbios do Início e da Manutenção do Sono
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Sleep
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
França