Dosimetric analysis of Tomotherapy-based intracranial stereotactic radiosurgery of brain metastasis.
Phys Med
; 52: 48-55, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-30139609
ABSTRACT
PURPOSE:
This paper analyzes Tomotherapy-based intracranial stereotactic radiosurgery (HTSRS) of brain metastasis targeting two end-points 1) evaluation of dose homogeneity, conformity and gradient scores for single and multiple lesions and 2) assay of dosimetric criticality of completion of HTSRS procedures.METHODS:
42 treatment plans of 33 patients (53 brain lesions) treated with HTSRS were analyzed. Dose to healthy brain, homogeneity, conformity and gradient indexes were evaluated for each lesion. Influence of Field Length and multiple lesions cross-talk effect were assessed. Treatment interruption and completion was investigated using radiochromic films in order to examine the delivered dose and its robustness to patient intrafraction movement.RESULTS:
The average dose homogeneity index was 1.04⯱â¯0.02 (SD). Average dose conformity and gradient score indexes were 1.4⯱â¯0.2 and 50⯱â¯14 respectively. We found a strong correlation of the dose to healthy brain and conformity and gradient indexes with target(s) volume for which analytical functions were obtained. Field Length and cross-talk effect were significantly correlated with poor gradient scores, but were found not to affect dose conformity.CONCLUSIONS:
Homogeneity and conformity of HTSRS plans achieved excellent scores, while dose falloff and dose to healthy brain were slightly larger when compared with non-coplanar SRS techniques. Care should be given if treating large (>3â¯cc) or multiple near in-plane lesions in order to reduce dose to healthy brain. Analysis of interrupted treatments suggests splitting HTSRS treatments in two consecutive fractions in order to prevent target miss and overdosage due to patient intrafraction movement.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dosagem Radioterapêutica
/
Neoplasias Encefálicas
/
Radiocirurgia
/
Radioterapia de Intensidade Modulada
Tipo de estudo:
Evaluation_studies
Limite:
Humans
Idioma:
En
Revista:
Phys Med
Assunto da revista:
BIOFISICA
/
BIOLOGIA
/
MEDICINA
Ano de publicação:
2018
Tipo de documento:
Article