Development of antiviral inhibitor against dengue 2 targeting Ns3 protein: In vitro and in silico significant studies.
Acta Trop
; 188: 1-8, 2018 Dec.
Article
em En
| MEDLINE
| ID: mdl-30145258
ABSTRACT
Dengue fever is a severe, widespread disease with more than 2 million diagnosed infections per year. The Dengue virus protease represents a cardinal target for prudent drug design. Among the four serotypes Dengue 2 is known for the occurrence of its frequent epidemics. The new compound inhibited the Dengue-2 in the low-micromolar range in cells. At the moment, protease inhibitors are not actively tried against dengue virus as therapeutic option. We have identified thiosemicarbazones derived phenyl-acetyl ketones as candidate for a novel class of protease inhibitors. Here, we report the selective and non-competitive inhibition of the Dengue virus serotype 2 in vitro and in silico. Molecular docking suggests binding at a specific active site. In addition to the docking assays, few techniques were developed to interpret these molecules's antiviral profile in vitro.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Inibidores de Proteases
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Serina Endopeptidases
/
Vírus da Dengue
Limite:
Animals
Idioma:
En
Revista:
Acta Trop
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Índia