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A Patient with Limbic Encephalitis Associated with Anti-leucine-rich Glioma-inactivated 1 (LGI1) Antibody Presenting with Slowly Progressive Cognitive Impairment and Fluctuating Striatal Lesions.
Sato, Mitsuto; Kishida, Dai; Miyazaki, Daigo; Sekijima, Yoshiki.
Afiliação
  • Sato M; Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
  • Kishida D; Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
  • Miyazaki D; Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
  • Sekijima Y; Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan.
Intern Med ; 58(2): 287-291, 2019 Jan 15.
Article em En | MEDLINE | ID: mdl-30146575
We herein report the case of a 59-year-old man with anti-leucine-rich glioma-inactivated 1 (LGI1) antibody encephalitis who presented with slowly progressive cognitive impairment mimicking dementia for over 3 years and then developed seizures. Unique brain magnetic resonance imaging (MRI) findings of fluctuating striatal lesions were observed during the disease course. He was treated with intravenous methylprednisolone pulse therapy followed by oral prednisolone, which dramatically improved his neurological function. Taken together, these findings indicate that anti-LGI1 encephalitis may present as slowly progressive cognitive impairment mimicking dementia and that fluctuating MRI striatal lesions may be a characteristic radiological finding of this disorder.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Encéfalo / Proteínas / Encefalite Límbica / Disfunção Cognitiva Tipo de estudo: Diagnostic_studies / Etiology_studies / Risk_factors_studies Limite: Humans / Male / Middle aged Idioma: En Revista: Intern Med Assunto da revista: MEDICINA INTERNA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão País de publicação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Encéfalo / Proteínas / Encefalite Límbica / Disfunção Cognitiva Tipo de estudo: Diagnostic_studies / Etiology_studies / Risk_factors_studies Limite: Humans / Male / Middle aged Idioma: En Revista: Intern Med Assunto da revista: MEDICINA INTERNA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão País de publicação: Japão