Spontaneous Proliferation of CD4<sup>+</sup> T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naïve CD8<sup>+</sup> T Cells.

Kim, Juhee; Lee, Jun Young; Cho, Kyungjin; Hong, Sung-Wook; Kim, Kwang Soon; Sprent, Jonathan; Im, Sin-Hyeog; Surh, Charles D; Cho, Jae-Ho

Spontaneous Proliferation of CD4⁺ T Cells in RAG-Deficient Hosts Promotes Antigen-Independent but IL-2-Dependent Strong Proliferative Response of Naïve CD8⁺ T Cells.

Kim, Juhee; Lee, Jun Young; Cho, Kyungjin; Hong, Sung-Wook; Kim, Kwang Soon; Sprent, Jonathan; Im, Sin-Hyeog; Surh, Charles D; Cho, Jae-Ho.

Afiliação

Kim J; Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, South Korea.
Lee JY; Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, South Korea.
Cho K; Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, South Korea.
Hong SW; Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, South Korea.
Kim KS; Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, South Korea.
Sprent J; Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, South Korea.
Im SH; Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, South Korea.
Surh CD; Department of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, South Korea.
Cho JH; Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, South Korea.

Front Immunol ; 9: 1907, 2018.

Article em En | MEDLINE | ID: mdl-30190718

Assuntos

Linfócitos T CD4-Positivos/imunologia; Linfócitos T CD4-Positivos/metabolismo; Linfócitos T CD8-Positivos/imunologia; Linfócitos T CD8-Positivos/metabolismo; Interleucina-2/metabolismo; Transferência Adotiva; Animais; Antígenos/imunologia; Bactérias/imunologia; Proliferação de Células; Memória Imunológica; Imunofenotipagem; Interleucina-2/genética; Ligantes; Ativação Linfocitária/imunologia; Camundongos; Ligação Proteica; Receptores de Antígenos de Linfócitos T/genética; Receptores de Antígenos de Linfócitos T/metabolismo

Palavras-chave

germ-free (GF); interleukin-2 (IL-2); lymphopenia-induced homeostatic proliferation; naïve CD4 T+ cells; naïve CD8+ T cells; specific pathogen-free (SPF); spontaneous proliferation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Interleucina-2 / Linfócitos T CD8-Positivos Limite: Animals Idioma: En Revista: Front Immunol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Coréia do Sul

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