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A high performance 2-hydroxynaphthalene Schiff base fluorescent chemosensor for Al3+ and its applications in imaging of living cells and zebrafish in vivo.
Tian, He; Qiao, Xin; Zhang, Zhen-Lei; Xie, Cheng-Zhi; Li, Qing-Zhong; Xu, Jing-Yuan.
Afiliação
  • Tian H; Department of Chemical Biology and Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.
  • Qiao X; Department of Chemical Biology and Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.
  • Zhang ZL; Department of Chemical Biology and Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.
  • Xie CZ; Department of Chemical Biology and Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.
  • Li QZ; The Laboratory of Theoretical and Computational Chemistry, School of Chemistry and Chemical Engineering, Yantai University, Yantai 264005, PR China.
  • Xu JY; Department of Chemical Biology and Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China. Electronic address: xujingyuan@tmu.edu.cn.
Article em En | MEDLINE | ID: mdl-30195183
Developing high performance fluorescent chemo-sensors for in vitro and in vivo Al3+ detection is highly desirable, because Al3+ accumulation has been involved to various diseases. Herein, we report a highly selective and sensitive Schiff base fluorescent probe, H3L, based on 2-hydroxynaphthalene, which can recognize aluminum ions and exhibit an "off-on" mode with high selectivity in methanol solutions. The detection limit of the probe for Al3+ is as low as 10-7 M which was determined by fluorescent titration. The high selectivity and high sensitivity of H3L for Al3+ are attributed to the inhibition of ESIPT. Additionally, the distribution of intracellular Al3+ ions could be observed under confocal fluorescence microscopy. Moreover, we also applied H3L for in vivo detection of Al3+ ions in living zebrafish larvae.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bases de Schiff / Alumínio / Imagem Óptica / Corantes Fluorescentes / Naftóis Limite: Animals / Female / Humans / Male Idioma: En Revista: Spectrochim Acta A Mol Biomol Spectrosc Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bases de Schiff / Alumínio / Imagem Óptica / Corantes Fluorescentes / Naftóis Limite: Animals / Female / Humans / Male Idioma: En Revista: Spectrochim Acta A Mol Biomol Spectrosc Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de publicação: Reino Unido