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Effect of diabetes mellitus type 1 diagnosis on the corneal cell densities and nerve fibers.
Ceská Burdová, M; Kulich, M; Dotrelová, D; Mahelková, G.
Afiliação
  • Ceská Burdová M; Department of Ophthalmology for Children and Adults, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic. gabriela.mahelkova@ lfmotol.cuni.cz; gabriela.mahelkova@fnmotol.cz.
Physiol Res ; 67(6): 963-974, 2018 12 18.
Article em En | MEDLINE | ID: mdl-30204467
Relation of diabetes mellitus (DM) to the various stages of corneal nerve fiber damage is well accepted. A possible association between changes in the cornea of diabetic patients and diabetic retinopathy (DR), DM duration, and age at the time of DM diagnosis were evaluated. The study included 60 patients with DM type 1 (DM1) and 20 healthy control subjects. The density of basal epithelial cells, keratocytes and endothelial cells, and the status of the subbasal nerve fibers were evaluated using in vivo corneal confocal microscopy. Basal epithelial cell density increased with age (p=0.026), while stromal and endothelial cell density decreased with age (p=0.003, p=0.0005, p<0.0001). After the DM1 diagnosis was established, this association with age weaken. We showed nerve fiber damage in DM1 patients (p<0.0001). The damage correlated with the degree of DR. DM1 patients with higher age at DM1 diagnosis had a higher nerve fiber density (p=0.0021). These results indicated that age at DM1 diagnosis potentially has an important effect on final nerve fiber and corneal cell density.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córnea / Diabetes Mellitus Tipo 1 / Retinopatia Diabética / Células Epiteliais / Fibras Nervosas Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Physiol Res Assunto da revista: FISIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de publicação: República Tcheca
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córnea / Diabetes Mellitus Tipo 1 / Retinopatia Diabética / Células Epiteliais / Fibras Nervosas Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Physiol Res Assunto da revista: FISIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de publicação: República Tcheca