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An Interleukin-1 beta (IL1B) haplotype linked with psychosis transition is associated with IL1B gene expression and brain structure.
Mostaid, Md Shaki; Dimitrakopoulos, Stefanos; Wannan, Cassandra; Cropley, Vanessa; Weickert, Cynthia Shannon; Everall, Ian P; Pantelis, Christos; Bousman, Chad A.
Afiliação
  • Mostaid MS; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Carlton South, VIC, Australia; The Cooperative Research Centre (CRC) for Mental Health, VIC, Australia.
  • Dimitrakopoulos S; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Carlton South, VIC, Australia; The Cooperative Research Centre (CRC) for Mental Health, VIC, Australia; 1st Department of Psychiatry, Athens University Medical School, Eginition Hospital,
  • Wannan C; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Carlton South, VIC, Australia; The Cooperative Research Centre (CRC) for Mental Health, VIC, Australia.
  • Cropley V; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Carlton South, VIC, Australia.
  • Weickert CS; Schizophrenia Research Laboratory, Neuroscience Research Australia, Barker Street, Sydney, Australia; School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Department of Neuroscience & Physiology, Upstate Medical University, Syracuse, New York 13210, USA.
  • Everall IP; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Carlton South, VIC, Australia; The Cooperative Research Centre (CRC) for Mental Health, VIC, Australia; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Par
  • Pantelis C; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Carlton South, VIC, Australia; The Cooperative Research Centre (CRC) for Mental Health, VIC, Australia; Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Par
  • Bousman CA; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Carlton South, VIC, Australia; The Cooperative Research Centre (CRC) for Mental Health, VIC, Australia; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada; Departments o
Schizophr Res ; 204: 201-205, 2019 02.
Article em En | MEDLINE | ID: mdl-30220520
We investigated IL1B genetic variation previously associated with risk for transition to psychosis for its association with gene expression in human post-mortem dorsolateral prefrontal cortex (DLPFC) from 74 (37 schizophrenia, 37 control) individuals and brain structure in 92 (44 schizophrenia, 48 control) living individuals. The IL1B A-G-T 'risk for psychosis transition' haplotype (rs16944|rs4848306|rs12621220) was associated with upregulation of IL1B mRNA expression in the DLPFC as well as reduced total grey matter and left middle frontal volumes and enlarged left lateral ventricular volume. Our results suggest IL1B genetic variation may confer psychosis risk via elevated mRNA expression and/or brain structure abnormalities.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Córtex Pré-Frontal / Ventrículos Laterais / Interleucina-1beta / Substância Cinzenta Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Schizophr Res Assunto da revista: PSIQUIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Austrália País de publicação: Holanda
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Córtex Pré-Frontal / Ventrículos Laterais / Interleucina-1beta / Substância Cinzenta Tipo de estudo: Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Schizophr Res Assunto da revista: PSIQUIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Austrália País de publicação: Holanda