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Extended Targeted and Non-Targeted Strategies for the Analysis of Marine Toxins in Mussels and Oysters by (LC-HRMS).
Dom, Inès; Biré, Ronel; Hort, Vincent; Lavison-Bompard, Gwenaëlle; Nicolas, Marina; Guérin, Thierry.
Afiliação
  • Dom I; Laboratory for Food Safety, ANSES, Université Paris-Est, F-94701 Maisons-Alfort, France. ines.dom@anses.fr.
  • Biré R; Agreenium, the French Agricultural, Veterinary and Forestry Institute, 75116 Paris, France. ines.dom@anses.fr.
  • Hort V; Laboratory for Food Safety, ANSES, Université Paris-Est, F-94701 Maisons-Alfort, France. ronel.bire@anses.fr.
  • Lavison-Bompard G; Laboratory for Food Safety, ANSES, Université Paris-Est, F-94701 Maisons-Alfort, France. vincent.hort@anses.fr.
  • Nicolas M; Laboratory for Food Safety, ANSES, Université Paris-Est, F-94701 Maisons-Alfort, France. gwenaelle.lavison-bompard@anses.fr.
  • Guérin T; Laboratory for Food Safety, ANSES, Université Paris-Est, F-94701 Maisons-Alfort, France. marina.nicolas@anses.fr.
Toxins (Basel) ; 10(9)2018 09 14.
Article em En | MEDLINE | ID: mdl-30223487
ABSTRACT
When considering the geographical expansion of marine toxins, the emergence of new toxins and the associated risk for human health, there is urgent need for versatile and efficient analytical methods that are able to detect a range, as wide as possible, of known or emerging toxins. Current detection methods for marine toxins rely on a priori defined target lists of toxins and are generally inappropriate for the detection and identification of emerging compounds. The authors describe the implementation of a recent approach for the non-targeted analysis of marine toxins in shellfish with a focus on a comprehensive workflow for the acquisition and treatment of the data generated after liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS) analysis. First, the study was carried out in targeted mode to assess the performance of the method for known toxins with an extended range of polarities, including lipophilic toxins (okadaic acid, dinophysistoxins, azaspiracids, pectenotoxins, yessotoxins, cyclic imines, brevetoxins) and domoic acid. The targeted method, assessed for 14 toxins, shows good performance both in mussel and oyster extracts. The non-target potential of the method was then challenged via suspects and without a priori screening by blind analyzing mussel and oyster samples spiked with marine toxins. The data processing was optimized and successfully identified the toxins that were spiked in the blind samples.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ostreidae / Poluentes da Água / Bivalves / Toxinas Marinhas Limite: Animals Idioma: En Revista: Toxins (Basel) Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ostreidae / Poluentes da Água / Bivalves / Toxinas Marinhas Limite: Animals Idioma: En Revista: Toxins (Basel) Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França