Changes in duodenal CD163-positive cells in dogs with chronic enteropathy after successful treatment.
Innate Immun
; 24(7): 400-410, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-30223681
ABSTRACT
Chronic enteropathy (CE) in dogs is characterized retrospectively per treatment response as food-responsive enteropathy (FRE), antibiotic-responsive enteropathy (ARE), and immunosuppressant-responsive enteropathy (IRE) - the latter most resembling inflammatory bowel disease in people. The aim of this study was to characterize duodenal macrophages (MÏ) in CE using immunohistochemistry; with calprotectin (CAL) as a marker of early differentiated MÏ and CD163 expression as a marker for resident MÏ in the duodenum before and after treatment. Prior to treatment, dogs with FRE and IRE had a lower CD163+/CAL+ ratio than control dogs (CTRL) in crypts; this increased significantly and normalized compared with CTRL after treatment. Conversely, the CD163+/CAL+ ratio in dogs with ARE was comparable to that in healthy dogs before and after treatment. In summary, these results suggest that MÏ play a role in the pathogenesis of CE in FRE and IRE, with a decrease in resident MÏ and an increase in early differentiated MÏ, but not in ARE dogs. MÏ normalize after successful treatment.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
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Duodeno
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Macrófagos
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Innate Immun
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
BACTERIOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Austrália