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Mannoside Glycolipid Conjugates Display Antiviral Activity Against Ebola Virus.
Reynard, Olivier; Schaeffer, Evelyne; Volchkova, Valentina A; Cimarelli, Andrea; Mueller, Christopher G; Volchkov, Viktor E.
Afiliação
  • Reynard O; Laboratory Molecular Basis of Viral Pathogenicity, Centre International de Recherche en Infectiologie, INSERM, University of Lyon, Université Claude Bernard Lyon, ENS de Lyon, CNRS, UMR, Lyon, France.
  • Schaeffer E; CNRS, Université de Strasbourg, UPR, Department of Immunology, Immunopathology and Therapeutic Chemistry, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.
  • Volchkova VA; Laboratory Molecular Basis of Viral Pathogenicity, Centre International de Recherche en Infectiologie, INSERM, University of Lyon, Université Claude Bernard Lyon, ENS de Lyon, CNRS, UMR, Lyon, France.
  • Cimarelli A; Laboratory Host Pathogen Interaction During Lentiviral Infection, Centre International de Recherche en Infectiologie, INSERM, University of Lyon, Université Claude Bernard Lyon, ENS de Lyon, CNRS, UMR, Lyon, France.
  • Mueller CG; CNRS, Université de Strasbourg, UPR, Department of Immunology, Immunopathology and Therapeutic Chemistry, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.
  • Volchkov VE; Laboratory Molecular Basis of Viral Pathogenicity, Centre International de Recherche en Infectiologie, INSERM, University of Lyon, Université Claude Bernard Lyon, ENS de Lyon, CNRS, UMR, Lyon, France.
J Infect Dis ; 218(suppl_5): S666-S671, 2018 11 22.
Article em En | MEDLINE | ID: mdl-30239745
ABSTRACT
The West African outbreak of Ebola virus (EBOV) infection during 2013-2016 highlighted the need for development of field-applicable therapeutic drugs for this infection. Here we report that mannoside glycolipid conjugates (MGCs) consisting of a trimannose head and a lipophilic chain assembled by a linker inhibit EBOV infection not only of human monocyte-derived dendritic cells and macrophages, but also of a number of susceptible cells. Analysis of the mode of action leads us to conclude that MGCs act directly on cells, notably by preventing virus endocytosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Glicolipídeos / Ebolavirus / Manosídeos Limite: Animals / Humans Idioma: En Revista: J Infect Dis Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Glicolipídeos / Ebolavirus / Manosídeos Limite: Animals / Humans Idioma: En Revista: J Infect Dis Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França