Recognizing the Molecular Multifunctionality and Interactome of TIMP-1.
Trends Cell Biol
; 29(1): 6-19, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30243515
ABSTRACT
Tissue inhibitor of metalloproteinase 1 (TIMP-1) is a major player in preserving tissue integrity and has recently also emerged as a decisive factor in several human pathologies. This appreciation has prompted this review addressing the largely underestimated complexity of the functions executed by TIMP-1 and their mechanistic basis. In fact, the versatile impact of TIMP-1 on cellular functions stems from its two-domain structure harboring metalloproteinase-inhibitory and cytokine-like signaling activities. This feature leads to functional interactions with numerous and distinct enzymatic and cell-surface proteins that initiate an exceptionally broad range of downstream effects. We propose here that this multifunctionality and the remarkably large interactome explain the diverse biological consequences of TIMP-1 expression in health and disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidor Tecidual de Metaloproteinase-1
/
Mapas de Interação de Proteínas
Limite:
Humans
Idioma:
En
Revista:
Trends Cell Biol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Canadá