Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects.

Syed, Ismail; Lee, Jennifer; Peroni, Odile D; Yore, Mark M; Moraes-Vieira, Pedro M; Santoro, Anna; Wellenstein, Kerry; Smith, Ulf; McGraw, Timothy E; Saghatelian, Alan; Kahn, Barbara B

Syed, Ismail; Lee, Jennifer; Peroni, Odile D; Yore, Mark M; Moraes-Vieira, Pedro M; Santoro, Anna; Wellenstein, Kerry; Smith, Ulf; McGraw, Timothy E; Saghatelian, Alan; Kahn, Barbara B.

Afiliação

Syed I; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Lee J; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Peroni OD; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Yore MM; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Moraes-Vieira PM; Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, Campinas-SP 13083-970, Brazil.
Santoro A; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Wellenstein K; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Smith U; The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
McGraw TE; Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.
Saghatelian A; Clayton Foundation Laboratories for Peptide Biology, Helmsley Center for Genomic Medicine, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: asaghatelian@salk.edu.
Kahn BB; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address: bkahn@bidmc.harvard.edu.

Cell Metab ; 28(4): 543-546, 2018 10 02.

Article em En | MEDLINE | ID: mdl-30244974

RESUMO

PAHSAs are anti-diabetic and anti-inflammatory lipids. Syed et al. identify numerous experimental differences that likely account for the failure of Pflimlin et al. to observe PAHSA beneficial effects. The differences include different HFDs resulting in minimal/no glucose intolerance, different assay conditions, an LC-MS protocol that was not validated, and use of olive oil, a bioactive nutrient that improves glucose tolerance, as a vehicle.

Assuntos

Glicemia; Lipídeos; Animais; Camundongos

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Lipídeos Limite: Animals Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google