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A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect ß-secretase inhibitors.
Gay, Marion; Evrard, Caroline; Descamps, Florian; Carato, Pascal; Renault, Nicolas; Coevoet, Mathilde; Eddarkaoui, Sabiha; Baud, Catherine; Larchanché, Paul-Emmanuel; Buée, Luc; El Bakali, Jamal; Vingtdeux, Valérie; Sergeant, Nicolas; Melnyk, Patricia.
Afiliação
  • Gay M; Université de Lille, Inserm, CHU Lille, UMR-S 1172, JPArc, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France.
  • Evrard C; Université de Lille, Inserm, CHU Lille, UMR-S 1172, JPArc, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France.
  • Descamps F; Université de Lille, Inserm, CHU Lille, UMR-S 1172, JPArc, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France.
  • Carato P; Université de Lille, Inserm, CHU Lille, UMR-S 1172, JPArc, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France.
  • Renault N; Université de Lille, Inserm, CHU Lille, U995, LIRIC, Lille Inflammation Research International Center, F-59000, Lille, France.
  • Coevoet M; Université de Lille, Inserm, CHU Lille, UMR-S 1172, JPArc, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France.
  • Eddarkaoui S; Université de Lille, Inserm, CHU Lille, UMR-S 1172, JPArc, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France.
  • Baud C; Université de Lille, Inserm, CHU Lille, UMR-S 1172, JPArc, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France.
  • Larchanché PE; Université de Lille, Inserm, CHU Lille, UMR-S 1172, JPArc, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France.
  • Buée L; Université de Lille, Inserm, CHU Lille, UMR-S 1172, JPArc, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France.
  • El Bakali J; Université de Lille, Inserm, CHU Lille, UMR-S 1172, JPArc, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France. Electronic address: jamal.el-bakali@univ-lille.fr.
  • Vingtdeux V; Université de Lille, Inserm, CHU Lille, UMR-S 1172, JPArc, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France. Electronic address: valerie.vingtdeux@inserm.fr.
  • Sergeant N; Université de Lille, Inserm, CHU Lille, UMR-S 1172, JPArc, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France.
  • Melnyk P; Université de Lille, Inserm, CHU Lille, UMR-S 1172, JPArc, Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France.
Eur J Med Chem ; 159: 104-125, 2018 Nov 05.
Article em En | MEDLINE | ID: mdl-30268822
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Precursor de Proteína beta-Amiloide / Secretases da Proteína Precursora do Amiloide / Descoberta de Drogas Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França País de publicação: França
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteases / Precursor de Proteína beta-Amiloide / Secretases da Proteína Precursora do Amiloide / Descoberta de Drogas Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: França País de publicação: França