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Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell.
Ruella, Marco; Xu, Jun; Barrett, David M; Fraietta, Joseph A; Reich, Tyler J; Ambrose, David E; Klichinsky, Michael; Shestova, Olga; Patel, Prachi R; Kulikovskaya, Irina; Nazimuddin, Farzana; Bhoj, Vijay G; Orlando, Elena J; Fry, Terry J; Bitter, Hans; Maude, Shannon L; Levine, Bruce L; Nobles, Christopher L; Bushman, Frederic D; Young, Regina M; Scholler, John; Gill, Saar I; June, Carl H; Grupp, Stephan A; Lacey, Simon F; Melenhorst, J Joseph.
Afiliação
  • Ruella M; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Xu J; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Barrett DM; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
  • Fraietta JA; Parker Institute for Cellular Immunotherapy at the University of Pennsylvania, Philadelphia, PA, USA.
  • Reich TJ; Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Ambrose DE; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Klichinsky M; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Shestova O; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
  • Patel PR; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Kulikovskaya I; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Nazimuddin F; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Bhoj VG; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
  • Orlando EJ; Parker Institute for Cellular Immunotherapy at the University of Pennsylvania, Philadelphia, PA, USA.
  • Fry TJ; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Bitter H; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Maude SL; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Levine BL; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Nobles CL; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Bushman FD; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Young RM; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Scholler J; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Gill SI; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • June CH; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
  • Grupp SA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
  • Lacey SF; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Melenhorst JJ; University of Colorado, Children's Hospital Colorado, Denver, CO, USA.
Nat Med ; 24(10): 1499-1503, 2018 10.
Article em En | MEDLINE | ID: mdl-30275568
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia / Resistencia a Medicamentos Antineoplásicos / Antígenos CD19 / Epitopos Limite: Adult / Humans / Male Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia / Resistencia a Medicamentos Antineoplásicos / Antígenos CD19 / Epitopos Limite: Adult / Humans / Male Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos