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Primary cardiac MYC/BCL6 double hit non-Hodgkin lymphoma.
Annibali, Ombretta; Nenna, Antonio; Barbato, Raffaele; Chello, Massimo; Sedati, Pietro; Bianchi, Antonella; Deda, Giuseppe; Avvisati, Giuseppe.
Afiliação
  • Annibali O; Unit of Hematology, Stem Cell Transplantation, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.
  • Nenna A; Unit of Heart Surgery, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.
  • Barbato R; Unit of Heart Surgery, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.
  • Chello M; Unit of Heart Surgery, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.
  • Sedati P; Unit of Anatomical Pathology, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.
  • Bianchi A; Unit of Diagnostic Imaging, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.
  • Deda G; Unit of Diagnostic Imaging, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.
  • Avvisati G; Unit of Hematology, Stem Cell Transplantation, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy.
J Cardiol Cases ; 17(3): 103-106, 2018 Mar.
Article em En | MEDLINE | ID: mdl-30279867
Cardiac and pericardial involvement by malignant lymphoma is a rare condition. The present case report describes a case of primary cardiac MYC/BCL6 double hit non-Hodgkin lymphoma in the pericardium, and highlights the importance of a prompt diagnosis and aggressive pharmacologic treatment of this disease. In a symptomatic patient, a minimally invasive 3 cm sub-xiphoidal incision was performed under deep sedation with spontaneous ventilation to perform a pericardial biopsy. A 5 cm × 3 cm portion of pericardium was removed from above the right ventricle, thus ameliorating the extrinsic compression on the right chambers. The patient received 6 cycles of immuno-chemotherapy (rituximab plus cyclophosphamide, vincristine, and methylprednisolone), with no complications, achieving complete remission with no symptoms. Malignancies must be excluded in every case of acute pericardial disease with imaging techniques, and lymphomas should be always considered in the differential diagnosis of cardiac tumors. Complete surgical removal of the tumor is not necessary to achieve complete remission, and minimally invasive surgical approaches are an effective tool to confirm diagnosis and allow a precise histologic characterization. .
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: J Cardiol Cases Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália País de publicação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: J Cardiol Cases Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália País de publicação: Japão