Oral Manifestations of Autoimmune Neutropenia: A Case Report.
J Clin Pediatr Dent
; 43(1): 46-50, 2019.
Article
em En
| MEDLINE
| ID: mdl-30289370
ABSTRACT
Autoimmune neutropenia is a self-limiting condition characterized by the presence of granulocyte-specific autoantibodies. This case report describes a 2-year-old female who presented to the Department of Pediatric Dentistry with a history of oral ulceration, complicated by high temperature, gingival hypertrophy and gingival hemorrhage. These symptoms had precipitated an admission to a district general hospital and diagnosis of viral tonsillitis. The severity of the presentation to the Pediatric Dental Department prompted a review of recent discharge blood investigations, which revealed a neutrophil count of 0.07×109/L(1.0-8.5 ×109/L) indicating severe neutropenia. Urgent referral to Pediatric Hematology resulted in same-day admission and a diagnosis of autoimmune neutropenia was established. The patient was managed with chlorhexidine mouthwash, prophylactic antimicrobial and antifungal medication and granulocyte colony stimulating factor (G-CSF). Neutropenia may present with features exclusive to the oral cavity. Recognition of atypical presentations such as oral ulceration with associated systemic illness may assist in early diagnosis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hemorragia Gengival
/
Úlceras Orais
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Hipertrofia Gengival
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Neutropenia
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Screening_studies
Limite:
Child
/
Child, preschool
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Female
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Humans
Idioma:
En
Revista:
J Clin Pediatr Dent
Assunto da revista:
ODONTOLOGIA
/
PEDIATRIA
Ano de publicação:
2019
Tipo de documento:
Article