Pharmacokinetics of Sildenafil in Patients with a Left Ventricular Assist Device: A Word of Caution.
ASAIO J
; 65(5): 530-532, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-30299299
ABSTRACT
We compared maximal plasma concentrations (Cmax) of sildenafil and metabolite n-desmethyl sildenafil in 12 inpatients with left ventricular assist devices (LVADs) on sildenafil (60 mg/day) to the reference range. Sildenafil Cmax (156.8 ± 124.5 ng/ml) was elevated in 66% of patients, with a two to fivefold increase over the upper limit of the reference range in 25% of patients. Metabolite Cmax (133.3 ± 102.0 ng/ml) was elevated in 75% of patients, with a three to sevenfold increase over the upper limit of the reference range in 40% of patients. Patients with heart failure and LVADs are at increased risk of concentrated-related sildenafil adverse events.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Coração Auxiliar
/
Inibidores da Fosfodiesterase 5
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Citrato de Sildenafila
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
ASAIO J
Assunto da revista:
TRANSPLANTE
Ano de publicação:
2019
Tipo de documento:
Article