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A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier.
Sturm, Stefan; Günther, Andreas; Jaber, Birgit; Jordan, Paul; Al Kotbi, Nada; Parkar, Nikhat; Cleary, Yumi; Frances, Nicolas; Bergauer, Tobias; Heinig, Katja; Kletzl, Heidemarie; Marquet, Anne; Ratni, Hasane; Poirier, Agnès; Müller, Lutz; Czech, Christian; Khwaja, Omar.
Afiliação
  • Sturm S; Roche Innovation Center, Basel, Switzerland.
  • Günther A; Roche Innovation Center, Basel, Switzerland.
  • Jaber B; Roche Innovation Center, Basel, Switzerland.
  • Jordan P; Roche Innovation Center, Basel, Switzerland.
  • Al Kotbi N; PRA Health Science, Zuidlaren, the Netherlands.
  • Parkar N; Roche Innovation Center, Welwyn, UK.
  • Cleary Y; Roche Innovation Center, Basel, Switzerland.
  • Frances N; Roche Innovation Center, Basel, Switzerland.
  • Bergauer T; Roche Innovation Center, Basel, Switzerland.
  • Heinig K; Roche Innovation Center, Basel, Switzerland.
  • Kletzl H; Roche Innovation Center, Basel, Switzerland.
  • Marquet A; Roche Innovation Center, Basel, Switzerland.
  • Ratni H; Roche Innovation Center, Basel, Switzerland.
  • Poirier A; Roche Innovation Center, Basel, Switzerland.
  • Müller L; Roche Innovation Center, Basel, Switzerland.
  • Czech C; Roche Innovation Center, Basel, Switzerland.
  • Khwaja O; Roche Innovation Center, Basel, Switzerland.
Br J Clin Pharmacol ; 85(1): 181-193, 2019 01.
Article em En | MEDLINE | ID: mdl-30302786
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Compostos Azo / Splicing de RNA / Fármacos Neuromusculares Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Adult / Humans / Male / Middle aged Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suíça País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Compostos Azo / Splicing de RNA / Fármacos Neuromusculares Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Adult / Humans / Male / Middle aged Idioma: En Revista: Br J Clin Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suíça País de publicação: Reino Unido