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Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a study.
Scheltens, Philip; Hallikainen, Merja; Grimmer, Timo; Duning, Thomas; Gouw, Alida A; Teunissen, Charlotte E; Wink, Alle Meije; Maruff, Paul; Harrison, John; van Baal, Caroline M; Bruins, Suzanne; Lues, Inge; Prins, Niels D.
Afiliação
  • Scheltens P; Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands. p.scheltens@vumc.nl.
  • Hallikainen M; University of Eastern Finland, Institute of Clinical Medicine, Kuopio, Finland.
  • Grimmer T; Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Duning T; Department of Neurology, University of Münster, Münster, Germany.
  • Gouw AA; Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
  • Teunissen CE; Department of Clinical Neurophysiology and MEG Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
  • Wink AM; Department of Clinical Chemistry, Neurochemistry Laboratory and Biobank, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
  • Maruff P; Department of Radiology, Nuclear Medicine and PET Research, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
  • Harrison J; Cogstate Ltd, Melbourne, Australia.
  • van Baal CM; Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.
  • Bruins S; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Lues I; Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands.
  • Prins ND; Probiodrug AG, Halle, Germany.
Alzheimers Res Ther ; 10(1): 107, 2018 10 12.
Article em En | MEDLINE | ID: mdl-30309389
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzimidazóis / Imidazolinas / Doença de Alzheimer Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimers Res Ther Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda País de publicação: Reino Unido
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzimidazóis / Imidazolinas / Doença de Alzheimer Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimers Res Ther Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda País de publicação: Reino Unido